NK Cells were first noticed for their ability to kill tumour cells without any priming or prior activation (in contrast to cytotoxic T cells, which need priming by antigen presenting cells). They are named for this ‘natural’ killing. Additionally, NK cells secrete cytokines such as IFNγ and TNFα, which act on other immune cells like Macrophage and Dendritic cells to enhance the immune response.
Most normal healthy cells express MHC I receptors which mark these cells as ‘self’. Inhibitory receptors on the surface of the NK cell recognise cognate MHC I, and this ‘switches off’ the NK cell, preventing it from killing. Cancer cells and infected cells often lose their MHC I, leaving them vulnerable to NK cell killing. Once the decision is made to kill, the NK releases cytotoxic granules containing perforin and granzymes, which leads to lysis of the target cell.
Patients deficient in NK numbers and the cytotoxicity levels, prove to be highly susceptible to Viruses, Pathogens, Aging Frailty, and cancer.
Natural Killer (NK) cells are often referred to as the "real anti-cancer warriors" because they play a crucial role in detecting and destroying abnormal cells, including cancer cells, without the need for prior exposure. NK cells are part of the innate immune system and provide rapid responses to infected or transformed cells.
The benefits of NK cells include their ability to target a broad spectrum of abnormal cells, their rapid response, and their involvement in immune surveillance. They help control viral infections and contribute to the body's defense against tumors. Overall, NK cells are essential components of the immune system, providing early and effective responses to various threats.
While Natural Killer (NK) cells primarily function as part of the immune system's defense against infections and cancer. Some of the benefits include:
Cellular Senescence Clearance: NK cells help in eliminating senescent cells, which are aging cells that have stopped dividing and can negatively impact surrounding tissues. Removing these cells contribute to healthier aging.
Enhanced Immune Function: As we age, the immune system tends to decline. Boosting NK cell activity enhances immune responses, providing better protection against infections and diseases associated with aging.
Cancer Prevention: Since NK cells are natural cancer killers, maintaining or enhancing their activity contribute to preventing the development of age-related cancers.
Tissue Repair and Regeneration: NK cells play a role in tissue repair and regeneration, which is crucial for maintaining overall health and preventing age-related degeneration.
The benefits of Natural Killer (NK) cell treatment for anti-aging and cancer prevention include:
Cancer Surveillance: NK cells are crucial for immune surveillance, actively identifying and eliminating abnormal cells, including cancer cells. Boosting NK cell activity enhance the body's ability to detect and eliminate cancerous cells early on.
Senescent Cell Clearance: NK cells contribute to the removal of senescent cells, which accumulate with age and can negatively impact tissues. Clearing these cells aid in preventing age-related degeneration and maintaining tissue health.
Enhanced Immune Function: Improving NK cell function strengthen overall immune responses, reducing the risk of infections and preventing the development of cancers associated with viral infections.
Tissue Repair and Regeneration: NK cells play a role in tissue repair and regeneration, contributing to overall health and slowing down the aging process.